Hierarchical Organization of Modularity in Metabolic Networks
Spatially or chemically isolated functional modules composed of several cellular components and carrying discrete functions are considered fundamental building blocks of cellular organization, but their presence in highly integrated biochemical networks lacks quantitative support. We show that the metabolic networks of 43 distinct organisms are organized into many small, highly connected topologic modules that combine in a hierarchical manner into larger, less cohesive units, with their number and degree of clustering following a power law. Within Escherichia coli, the uncovered hierarchical modularity closely overlaps with known metabolic functions.
- The story:
- Publications:
- E. Ravasz, A. L. Somera, D. A. Mongru, Z. N. Oltvai and A.-L. Barabási,
Hierarchical organization of modularity in metabolic networks, Science, 297, 1551 (2002);
Supplementary Material. - S. Y. Gerdes, M. D. Scholle, J. W. Campbell, G. Balázsi, E. Ravasz, M. D. Daugherty, A. L. Somera, N. C. Kyrpides, I. Anderson, M. S. Gelfand, A. Bhattacharya, V. Kapatral, M. D’Souza, M. V. Baev, Y. Grechkin, F. Mseeh, M. Y. Fonstein, R. Overbeek, A.-L. Barabási, Z. N. Oltvai, and A. L. Osterman,
Experimental Determination and System Level Analysis of Essential Genes in Escherichia coli MG1655, Journal of Bacteriology, 185, 5673 (2003);
- E. Ravasz, A. L. Somera, D. A. Mongru, Z. N. Oltvai and A.-L. Barabási,
- Collaborators:
- Albert-László Barabási, Emil T. Hofman Professor of Physics
University of Notre Dame, Department of Physics - Zoltán Oltvai, Professor
University of Pittsburgh Medical Center, Department of Pathology
- Albert-László Barabási, Emil T. Hofman Professor of Physics
- Presentations:
- Hierarchical Modularity in Metabolic Networks (Slides)
Los Alamos National Laboratory – Arizona Days 2005, January 28 – 29, 2005, Tucson, AZ. - Hierarchical Modularity of Metabolic Networks (Poster)
Indiana Biocomplexity Symposium, April 22 – 23, 2003, University of Notre Dame, Notre Dame, IN.
- Hierarchical Modularity in Metabolic Networks (Slides)