Independent Study in the Regan Lab
2018-19
- Afton Widdershins (BCMB) – Investigating the Development and Behavior of Heterogeneous Tumors
Abstract: Several advancements in cancer treatment center on the idea that mutations in a tumor can be targeted with drugs. However, the presence of intratumor heterogeneity can complicate using targeted therapies as tumors can escape through the presence of an already resistant subclone or through developing resistance. Using a Boolean model of the regulatory network of a mammalian cell, we have constructed a simulation of a cell population, where each cell runs their own instance of said model. Working with the simulation showed that populations will evolve a response to high levels of TRAIL. The model also showed that low mutation rates tend to be more fit than high mutation rates, though the fitness of various mutation rates differs depending on the level of TRAIL stress. These results support the idea that cells susceptible to treatment can outcompete resistant cells given the proper stress conditions.
- Carolina Shams (Neuro-BCMB) –
Abstract:
- Eric Guberman (BCMB) – A Boolean Model of Contact Inhibition of Proliferation
Abstract: