{"id":841,"date":"2023-05-18T18:51:29","date_gmt":"2023-05-18T18:51:29","guid":{"rendered":"https:\/\/erzsoregan.voices.wooster.edu\/?page_id=841"},"modified":"2023-05-18T18:51:29","modified_gmt":"2023-05-18T18:51:29","slug":"caitlin-strassburg","status":"publish","type":"page","link":"https:\/\/erzsoregan.voices.wooster.edu\/?page_id=841","title":{"rendered":"Caitlin Strassburg"},"content":{"rendered":"\n<h3 class=\"wp-block-heading has-medium-font-size\">Conservation of Dynamic Modularity in the Regulation of Cell Cycle and Apoptosis control in <em>Saccharomyces cerevisiae<\/em><\/h3>\n\n\n\n<p><strong>Class of 2023<\/strong><\/p>\n\n\n\n<p><strong>Biography<\/strong><\/p>\n\n\n<div class=\"wp-block-image is-style-rounded\">\n<figure class=\"alignright size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/erzsoregan.voices.wooster.edu\/wp-content\/uploads\/sites\/104\/2023\/05\/Caitlin.png\" alt=\"\" class=\"wp-image-859\" width=\"300\" height=\"300\" srcset=\"https:\/\/erzsoregan.voices.wooster.edu\/wp-content\/uploads\/sites\/104\/2023\/05\/Caitlin.png 400w, https:\/\/erzsoregan.voices.wooster.edu\/wp-content\/uploads\/sites\/104\/2023\/05\/Caitlin-300x300.png 300w, https:\/\/erzsoregan.voices.wooster.edu\/wp-content\/uploads\/sites\/104\/2023\/05\/Caitlin-150x150.png 150w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure>\n<\/div>\n\n\n<ul class=\"wp-block-list\">\n<li><em>Education<\/em>\n<ul class=\"wp-block-list\">\n<li>Warren Area High School, Warren, PA, 2019<\/li>\n\n\n\n<li>The College of Wooster, BA in Biochemistry &amp; Molecular Biology, 2023<\/li>\n\n\n\n<li>The College of Wooster, BA in Mathematics, 2023<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><em>Professional experience<\/em>\n<ul class=\"wp-block-list\">\n<li>The College of Wooster Biology Department, Teaching Assistant <\/li>\n\n\n\n<li>The College of Wooster Biology Department, Research Assistant<\/li>\n\n\n\n<li>The College of Wooster Math &amp; Computer Science Department, Math Center Tutor<\/li>\n\n\n\n<li>The College of Wooster STEM Success Initiative, Teaching Assistant &amp; Peer Tutor<\/li>\n\n\n\n<li>The Cleveland Clinic LRI, Research Student<\/li>\n\n\n\n<li>Systems Approaches To Cancer Biology Scholar, 2022 <\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>IS Thesis Abstract<\/strong><\/p>\n\n\n\n<p>Dynamic Modularity is a proposed characteristic of biologically defined Boolean Regulatory Networks. The principle states that when modular networks regulating individual cell behaviors are connected according to biological interactions, the phenotypes of the newly formed network will be discrete combinations of each constituent switch\u2019s phenotypes. This hypothesized phenomenon has only yet been studied in the regulatory networks of mammalian cell cycle and apoptosis. Here we introduce a Boolean regulatory network for cell cycle control in&nbsp;<em>S. cerevisiae&nbsp;<\/em>consisting of two modular networks. The two constituent switches represent the Restriction\/START and Spindle Assembly Checkpoints of the cell cycle. This model is shown to reliably replicate the dynamics of the Restriction\/START and Spindle Assembly Checkpoints in the cell cycle of&nbsp;<em>S. cerevisiae.&nbsp;<\/em>Notably, the model doesn\u2019t not replicate the dynamics of the DNA damage checkpoint biologically observed in phase G2 of the cell cycle. Each constituent switch displays bistable dynamics consistent with their biological regulatory role. The modular nature of this model makes it a promising target for evaluating the presence of Dynamic Modularity in a novel model organism.<\/p>\n\n\n<div class=\"wp-block-image is-style-default\">\n<figure class=\"alignleft size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"421\" src=\"https:\/\/erzsoregan.voices.wooster.edu\/wp-content\/uploads\/sites\/104\/2023\/05\/Cailtin_web_IS_figure-1024x421.png\" alt=\"\" class=\"wp-image-843\" srcset=\"https:\/\/erzsoregan.voices.wooster.edu\/wp-content\/uploads\/sites\/104\/2023\/05\/Cailtin_web_IS_figure-1024x421.png 1024w, https:\/\/erzsoregan.voices.wooster.edu\/wp-content\/uploads\/sites\/104\/2023\/05\/Cailtin_web_IS_figure-300x123.png 300w, https:\/\/erzsoregan.voices.wooster.edu\/wp-content\/uploads\/sites\/104\/2023\/05\/Cailtin_web_IS_figure-768x316.png 768w, https:\/\/erzsoregan.voices.wooster.edu\/wp-content\/uploads\/sites\/104\/2023\/05\/Cailtin_web_IS_figure-1536x631.png 1536w, https:\/\/erzsoregan.voices.wooster.edu\/wp-content\/uploads\/sites\/104\/2023\/05\/Cailtin_web_IS_figure-2048x842.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><strong>Figure 1.<\/strong> The molecular network of yeast cell cycle control (left), and the cyclic division pattern it generates (right; orange = ON, blue = OFF). <\/figcaption><\/figure>\n<\/div>\n\n<div class=\"wp-block-image is-style-default\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/erzsoregan.voices.wooster.edu\/wp-content\/uploads\/sites\/104\/2023\/05\/image003-1024x683.jpg\" alt=\"\" class=\"wp-image-860\" srcset=\"https:\/\/erzsoregan.voices.wooster.edu\/wp-content\/uploads\/sites\/104\/2023\/05\/image003-1024x683.jpg 1024w, https:\/\/erzsoregan.voices.wooster.edu\/wp-content\/uploads\/sites\/104\/2023\/05\/image003-300x200.jpg 300w, https:\/\/erzsoregan.voices.wooster.edu\/wp-content\/uploads\/sites\/104\/2023\/05\/image003-768x512.jpg 768w, https:\/\/erzsoregan.voices.wooster.edu\/wp-content\/uploads\/sites\/104\/2023\/05\/image003-1536x1024.jpg 1536w, https:\/\/erzsoregan.voices.wooster.edu\/wp-content\/uploads\/sites\/104\/2023\/05\/image003-2048x1365.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><strong>Figure 2. <\/strong>Caitlin presenting her work at the 2023 IS Symposium<\/figcaption><\/figure>\n<\/div>\n\n\n<p><strong>Webpage:\u00a0<\/strong><a href=\"https:\/\/www.linkedin.com\/in\/caitlin-strassburg-0a8402167\/\" data-type=\"URL\" data-id=\"https:\/\/www.linkedin.com\/in\/caitlin-strassburg-0a8402167\/\">https:\/\/www.linkedin.com\/in\/caitlin-strassburg-0a8402167\/<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Conservation of Dynamic Modularity in the Regulation of Cell Cycle and Apoptosis control in Saccharomyces cerevisiae Class of 2023 Biography IS Thesis Abstract Dynamic Modularity is a proposed characteristic of biologically defined Boolean Regulatory Networks. The principle states that when &hellip; <a href=\"https:\/\/erzsoregan.voices.wooster.edu\/?page_id=841\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":276,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-841","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/erzsoregan.voices.wooster.edu\/index.php?rest_route=\/wp\/v2\/pages\/841","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/erzsoregan.voices.wooster.edu\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/erzsoregan.voices.wooster.edu\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/erzsoregan.voices.wooster.edu\/index.php?rest_route=\/wp\/v2\/users\/276"}],"replies":[{"embeddable":true,"href":"https:\/\/erzsoregan.voices.wooster.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=841"}],"version-history":[{"count":3,"href":"https:\/\/erzsoregan.voices.wooster.edu\/index.php?rest_route=\/wp\/v2\/pages\/841\/revisions"}],"predecessor-version":[{"id":862,"href":"https:\/\/erzsoregan.voices.wooster.edu\/index.php?rest_route=\/wp\/v2\/pages\/841\/revisions\/862"}],"wp:attachment":[{"href":"https:\/\/erzsoregan.voices.wooster.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=841"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}